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Article

Inherited predisposition to cancer: a historical overview.

American journal of medical genetics. Part C, Seminars in medical genetics - 15 Aug 2004

Lynch Henry T, Shaw Trudy G, Lynch Jane F

Abstract excerpt

The hereditary predisposition to cancer dates historically to interest piqued by physicians as well as family members wherein striking phenotypic features were shown to cluster in families, inclusive of the rather grotesque cutaneous findings in von Recklinghausen's neurofibromatosis, which date back to the sixteenth century. The search for the role of primary genetic factors was heralded by studies at the...

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Source

Identifiers

PMID: 15264268
DOI: 10.1002/ajmg.c.30026

Genes

APC
BRCA1
BRCA2
MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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