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Article

MAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myeloma

6 Jul 2018

Abstract excerpt

BACKGROUND: Multiple myeloma (MM) patients with t(14;20) have a poor prognosis and their outcome has not improved following the introduction of bortezomib (Bzb). The mechanism underlying the resistance to proteasome inhibitors (PIs) for this subset of patients is unknown. METHODS: IC50 of Bzb and carfilzomib (CFZ) in human myeloma cell lines (HMCLs) were established by MTT assay. Gene Expression profile (GEP)...

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PMID: 29980194
DOI: 10.1186/s12885-018-4602-4

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