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Ca<sup>2+</sup> and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing

1 Apr 2004

Abstract excerpt

Normal brain ageing is associated with a degree of functional impairment of neuronal activity that results in a reduction in memory and cognitive functions. One mechanism proposed to explain the age-dependent changes was the "Ca(2+) hypothesis of ageing" but data accumulated in the last decade revealed a number of inconsistencies. Two important questions were raised: (a) which are, if any, the most reliable...

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PMID: 15256066
DOI: 10.1111/j.1582-4934.2004.tb00273.x

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