Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Oocytes Reversibly Arrested in Prophase I by Phosphodiesterase Type 3 Inhibitor In Vitro1

1 Sept 2003

Abstract excerpt

This study addresses the role of cAMP hydrolytic isoenzyme phosphodiesterase type 3 (PDE 3) modulation on human oocyte maturation in vitro. Presence of phosphodiesterase type 3 A (PDE 3A) mRNA was confirmed in human germinal vesicle-stage (GV) oocytes. Making use of a selective PDE 3 inhibitor, Org 9935 (10 microM), oocytes retrieved from immature follicles were arrested in prophase I with a high efficiency for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phosphodiesterase function and regulation
Share to Reproductive Biology and Fertility
Share to Sexual function and dysfunction studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12773402
DOI: 10.1095/biolreprod.103.015982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Oocytes Reversibly Arrested in Prophase I by Phosphodiesterase Type 3 Inhibitor In Vitro1PMID 12773402Read ↗

Meiotic Arrest In Vitro by Phosphodiesterase 3-Inhibitor Enhances Maturation Capacity of Human Oocytes and Allows Subsequent Embryonic Development1Semantic proximity Read ↗

Effect of temporary nuclear arrest by Phosphodiesterase 3‐Inhibitor on morphological and functional aspects of in vitro matured mouse oocytesSemantic proximity Read ↗

Effects of cilostamide and forskolin on the meiotic resumption and embryonic development of immature human oocytesSemantic proximity Read ↗

Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents.Semantic proximity Read ↗

Prematuration of human denuded oocytes in a three-dimensional co-culture system: effects on meiosis progression and developmental competenceSemantic proximity Read ↗

Meiotic Arrest in Human Oocytes Is Maintained by a Gs Signaling Pathway1Semantic proximity Read ↗

The Effect of Cilostamide on Gap Junction Communication Dynamics, Chromatin Remodeling, and Competence Acquisition in Pig Oocytes Following Parthenogenetic Activation and Nuclear Transfer1Semantic proximity Read ↗

Human oocyte maturation in vitroSemantic proximity Read ↗

Maturation promoting factor destabilization mediates human chorionic gonadotropin induced meiotic resumption in rat oocytesSemantic proximity Read ↗

Maturation of human oocytes in vitro and their developmental competenceSemantic proximity Read ↗

Maturation of human oocytes in vitro and their developmental competenceSemantic proximity Read ↗

Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.