Article

Hsp70 incompletely disaggregates the misfolding K488X-menin, promoting the tumorigenesis in a multiple endocrine neoplasia type 1 family

2024-11-11

Abstract excerpt

<title>Abstract</title> <p>Previous standpoints involved into the nonsense mutations and missense variants which caused truncated inactive menin protein of <italic>Multiple Endocrine Neoplasia Type 1</italic>(<italic>MEN1</italic>) gene, including loss of heterozygosity(LOH) and menin mutants degradation, cannot wholly interpret MEN1 pathogenesis. A c.1462A > T (p.K488X) mutation in exon10 of <italic>MEN1</italic...

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Literature Corpus work: 7143be85-ca49-5f57-814b-2ab7f5260af7
DOI: 10.21203/rs.3.rs-5312614/v1

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