Article
Development of a cancer DNA phenotype prior to tumor formation.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004
Malins Donald C, Anderson Katie M, Gilman Naomi K, Green Virginia M, Barker Edward A, Hellström Karl Erik
Abstract excerpt
Using the carcinogen 3-methylcholanthrene (MCA), we demonstrate with Fourier transform-infrared spectroscopy that a cancer DNA phenotype is produced well in advance of palpable tumors. We further demonstrate that the administration of cyclophosphamide markedly inhibits the development of the cancer phenotype and concomitantly delays tumor formation. MCA, injected into the hind legs of mice, produced a variety of...
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