Article
A cancer DNA phenotype in healthy prostates, conserved in tumors and adjacent normal cells, implies a relationship to carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005
Malins Donald C, Gilman Naomi K, Green Virginia M, Wheeler Thomas M, Barker Edward A, Anderson Katie M
Abstract excerpt
A cancer DNA phenotype, identical to the DNA structure of tumors, has been identified in the prostate glands of certain healthy men over 55 years of age. We now show that the same DNA signature exists in normal tissues adjacent to tumors. This finding implies that the phenotype is maintained in normal prostate cells from its inception through tumor development. The presence of the phenotype in tumors, adjacent...
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