Article
Filling the gap between chemical carcinogenesis and the hallmarks of cancer: A temporal perspective.
European journal of clinical investigation - 1 Jun 2018
Demetriou Christiana A, Degli Esposti Davide, Pullen Fedinick Kristi, Russo Federica, Robinson Oliver, Vineis Paolo
Abstract excerpt
BACKGROUND: Cancer is believed to arise through the perturbation of pathways and the order of pathway perturbation events can enhance understanding and evaluation of carcinogenicity. This order has not been examined so far, and this study aimed to fill this gap by attempting to gather evidence on the potential temporal sequence of events in carcinogenesis. DESIGN: The methodology followed was to discuss first the...
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