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Article

In vitro selection of state-specific peptide modulators of G protein signaling using mRNA display.

Biochemistry - 20 Jul 2004

Ja William W, Roberts Richard W

Abstract excerpt

The G protein regulatory (GPR) motif is a approximately 20-residue conserved domain that acts as a guanine dissociation inhibitor (GDI) for G(i/o)(alpha) subunits. Here, we describe the isolation of peptides derived from a GPR consensus sequence using mRNA display selection libraries. Biotinylated G(i)(alpha)(1), modified at either the N or C terminus, serves as a high-affinity binding target for mRNA-displayed...

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Identifiers

PMID: 15248784
DOI: 10.1021/bi0498398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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