Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.

doi:10.1126/science.1098632

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Article

Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.

Science (New York, N.Y.) - 23 Jul 2004

Hazuda Daria J, Young Steven D, Guare James P, Anthony Neville J, Gomez Robert P, Wai John S, Vacca Joseph P, Handt Larry, Motzel Sherri L, Klein Hilton J, Dornadula Geethanjali, Danovich Robert M, Witmer Marc V, Wilson Keith A A, Tussey Lynda, Schleif William A, Gabryelski Lori S, Jin Lixia, Miller Michael D, Casimiro Danilo R, Emini Emilio A, Shiver John W

Abstract excerpt

We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression of viremia, preserving CD4 levels and permitting the induction of virus-specific cellular immunity. L-870812 was also active in chronic infection; however,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 15247437
DOI: 10.1126/science.1098632

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