The Extent and Significance of Telomere Loss with Age

Abstract excerpt

By imposing a limit on the proliferative life span of some human cell types, telomere loss and the subsequent onset of replicative senescence have been proposed to contribute to age-related disease. Although there is a large body of in vitro data to reveal the mechanisms by which telomere erosion triggers senescence, technical limitations have hampered our ability to understand the full extent of telomere erosion...

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