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Telomeres and Telomere Length: A General Overview

28 Feb 2020

Abstract excerpt

Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres undergo age-dependent incremental attrition. Short or...

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PMID: 32121056
DOI: 10.3390/cancers12030558

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