Article
The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism.
Annals of the New York Academy of Sciences - 1 Jun 2004
Corder Elizabeth H, Ghebremedhin Estifanos, Taylor Miles G, Thal Dietmar R, Ohm Thomas G, Braak Heiko
Abstract excerpt
Epidemiologic studies indicate that elderly women are at higher risk for Alzheimer disease compared to men. In order to pathologically verify this result, the extent of AD brain lesions (NFT and SP) was compared for men and women at each age, that is, at each decade from 25 years to 95 years, in a large sample of > 5000 routine autopsy cases. Women had more affected brain regions beginning in late middle age....
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