Article
Influence of genetic background on alcohol drinking and behavioral phenotypes of 5-HT3 receptor over-expressing mice.
Pharmacology, biochemistry, and behavior - 1 May 2006
Metz Amber V, Chynoweth Julie, Allan Andrea M
Abstract excerpt
Behavioral effects of genetic manipulations are influenced by the background genetics of mouse strains used for the creation of transgenic mice. One strategy to address whether background genes may compromise interpretation of phenotype is the production of congenics. 5-HT3 receptor over-expressing mice have been behaviorally characterized on a B6SJL/F2 background (B6SJL/F2-OE mice), and were found to consume...
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