Article
The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2004
Gifford Gillian, Paul Jim, Vasey Paul A, Kaye Stanley B, Brown Robert
Abstract excerpt
Aberrant epigenetic regulation, such as CpG island methylation and associated transcriptional silencing of genes, has been implicated in a variety of human diseases, including cancer. Methylation of genes involved in apoptosis, including the DNA mismatch repair (MMR) gene hMLH1, can occur in tumor models of resistance to chemotherapeutic drugs. However, the relevance for acquired resistance to chemotherapy of...
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