Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The PDGF/VEGF receptor controls blood cell survival in Drosophila.

Developmental cell - 1 Jul 2004

Brückner Katja, Kockel Lutz, Duchek Peter, Luque Carlos M, Rørth Pernille, Perrimon Norbert

Abstract excerpt

The Drosophila PDGF/VEGF receptor (PVR) has known functions in the guidance of cell migration. We now demonstrate that during embryonic hematopoiesis, PVR has a role in the control of antiapoptotic cell survival. In Pvr mutants, a large fraction of the embryonic hemocyte population undergoes apoptosis, and the remaining blood cells cannibalistically phagocytose their dying peers. Consequently, total hemocyte...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Cells
Share to Cell Aggregation
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Models, Animal

Share to Phagocytosis

Share to ras Proteins

Share to Receptor Protein-Tyrosine Kinases

Source

Identifiers

PMID: 15239955
DOI: 10.1016/j.devcel.2004.06.007

Genes

PVR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PDGF/VEGF receptor controls blood cell survival in Drosophila.PMID 15239955Read ↗

The Drosophila platelet-derived growth factor and vascular endothelial growth factor-receptor related (Pvr) protein ligands Pvf2 and Pvf3 control hemocyte viability and invasive migration.Semantic proximity Read ↗

Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors.Semantic proximity Read ↗

Hematopoietic stem cell-specific GFP-expressing transgenic mice generated by genetic excision of a pan-hematopoietic reporter gene.Semantic proximity Read ↗

Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alphaSemantic proximity Read ↗

PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst.Semantic proximity Read ↗

An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system.Semantic proximity Read ↗

Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in DrosophilaSemantic proximity Read ↗

Tools Allowing Independent Visualization and Genetic Manipulation ofDrosophila melanogasterMacrophages and Surrounding TissuesSemantic proximity Read ↗

Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolutionSemantic proximity Read ↗

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.Semantic proximity Read ↗

The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cellsSemantic proximity Read ↗

Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.