A novel splice variant involving the 5' untranslated region of thyroid hormone receptor beta1 (TRbeta1).

doi:10.1007/BF03351055

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Article

A novel splice variant involving the 5' untranslated region of thyroid hormone receptor beta1 (TRbeta1).

Journal of endocrinological investigation - 1 Apr 2004

Mannavola D, Moeller L C, Beck-Peccoz P, Persani L, Weiss R E, Refetoff S

Abstract excerpt

The thyroid hormone receptor beta (TRbeta) gene generates two different proteins by use of a different promoter (beta1 and beta2). We now report a novel short TRbeta1 RNA splice variant in humans lacking 35 nucleotides at the 3' end of the non-coding exon 1 due to an alternative 5' splice donor site. This short variant was first identified in sequences of cDNA obtained from cultured human fibroblasts. Both...

Topics

5' Untranslated Regions
Alternative Splicing
Base Sequence
Cells, Cultured
Fibroblasts
Genetic Variation
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
RNA, Messenger
Thyroid Hormone Receptors beta
Thyroid Hormone Resistance Syndrome
Triiodothyronine

Source

Open in PubMed

Identifiers

PMID: 15233549
DOI: 10.1007/BF03351055

Provenance

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