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Early Transcription from Nonintegrated DNA in Human Immunodeficiency Virus Infection

11 Sept 2003

Abstract excerpt

Replication of human immunodeficiency virus (HIV) involves obligatory sequential processes. Following viral entry and reverse transcription, the newly synthesized viral DNA integrates into the host chromatin. Integration is mandatory for viral production, yet HIV infection of CD4 T cells in vivo results in high levels of nonintegrated DNA. The biological potential of nonintegrated HIV DNA is unclear; however,...

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PMID: 12970422
DOI: 10.1128/jvi.77.19.10376-10382.2003

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