Article
Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2004
Li Guojun, Sturgis Erich M, Wang Li-E, Chamberlain Robert M, Spitz Margaret R, El-Naggar Adel K, Hong Waun K, Wei Qingyi
Abstract excerpt
PURPOSE: Abnormalities in p27 may alter cell cycle delay required for DNA repair after exposure to carcinogens. A coding exon 1 polymorphism at codon 109 (T-->G) in p27 was identified and thought to have an effect on the functions of its protein. We hypothesized that this p27 T109G polymorphism is associated with squamous cell carcinoma of the head and neck (SCCHN) risk. EXPERIMENTAL DESIGN: We tested this...
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