Article
Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3.
The European journal of neuroscience - 1 Jun 2004
McMahon Anne, Fowler Stephen C, Perney Teresa M, Akemann Walther, Knöpfel Thomas, Joho Rolf H
Abstract excerpt
Double-mutant mice (DKO) lacking the two voltage-gated K(+) channels Kv3.1 and Kv3.3 display a series of phenotypic alterations that include ataxia, myoclonus, tremor and alcohol hypersensitivity. The prominent cerebellar expression of mRNAs encoding Kv3.1 and Kv3.3 subunits raised the question a...
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