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Article

Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.

Infection and immunity - 1 Jul 2004

Liu Qian, Arseculeratne Cristin, Liu Zhugong, Whitmire Jeannette, Grusby Michael J, Finkelman Fred D, Darling Thomas N, Cheever Allen W, Swearengen James, Urban Joseph F, Gause William C

Abstract excerpt

A mouse lacking CD28, a T-cell costimulatory molecule, and STAT6, a transcription factor that mediates interleukin-4 (IL-4) signaling, was developed from parental CD28- and STAT6-deficient mice. STAT6/CD28(-/-) BALB/c mice that were 8 weeks old had a normal phenotype, and IL-4 production was indu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15213110
DOI: 10.1128/IAI.72.7.3706-3715.2004
PMCID: PMC427407

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15213110-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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