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Article

Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt.

Oncogene - 29 Jul 2004

Asnaghi Laura, Calastretti Angela, Bevilacqua Annamaria, D'Agnano Igea, Gatti Giuliana, Canti Gianfranco, Delia Domenico, Capaccioli Sergio, Nicolin Angelo

Abstract excerpt

The serine/threonine kinase mTOR, the major sensor of cell growth along the PI3K/Akt pathway, can be activated by agents acting on microtubules. Damaged microtubules induce phosphorylation of the Bcl-2 protein and lower the threshold of programmed cell death, both of which are inhibited by rapamycin. In HEK293 cells expressing Akt mutants, the level of Bcl-2 phosphorylation and the threshold of apoptosis induced...

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PMID: 15208671
DOI: 10.1038/sj.onc.1207698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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