Article
Origin of pathogenic macrophages and endoneurial fibroblast-like cells in an animal model of inherited neuropathy.
Molecular and cellular neurosciences - 1 Jul 2003
Mäurer Mathias, Müller Marcus, Kobsar Igor, Leonhard Christine, Martini Rudolf, Kiefer Reinhard
Abstract excerpt
Macrophages have recently been shown to be critically involved in the pathogenesis of genetically determined demyelination in mice heterozygously deficient for P0 (P0(+-)). Since little is known about the origin of these cells, we created chimeric P0(+-) mice by transplanting bone marrow from green fluorescent protein (GFP)-transgenic mice into irradiated P0(+-) mice. When analyzing chimeric P0(+-) mice, we could...
Topics
- Animals
- Bone Marrow Transplantation
- Cell Movement
- Disease Models, Animal
- Fibroblasts
- Green Fluorescent Proteins
- Luminescent Proteins
- Macrophages
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Microscopy, Immunoelectron
- Myelin Sheath