Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of adipose-derived stromal/stem cells from the Twitcher mouse model of Krabbe disease.

BMC cell biology - 16 Apr 2013

Zhang Xiujuan, Semon Julie A, Zhang Shijia, Strong Amy L, Scruggs Brittni A, Gimble Jeffrey M, Bunnell Bruce A

Abstract excerpt

BACKGROUND: Krabbe disease, also known as globoid cell leukodystrophy, is an autosomal recessive neurodegenerative disease caused by the genetic deficiency of galactocerebrosidase (GALC), a lysosomal enzyme responsible for the degradation of several glycosphingolipids like psychosine and galactosylceramide. In order to investigate whether GALC deficiency in Krabbe disease affects adipose-derived stromal/stem cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Cell Communication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Coculture Techniques

Share to Galactosylceramidase

Share to Leukodystrophy, Globoid Cell

Share to Osteogenesis

Share to Stromal Cells

Share to Subcutaneous Fat

Source

Open in PubMed Open full text

Identifiers

PMID: 23590629
DOI: 10.1186/1471-2121-14-20
PMCID: PMC3662570

Genes

GALC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of adipose-derived stromal/stem cells from the Twitcher mouse model of Krabbe disease.PMID 23590629Read ↗

Neural stem cell compartments in a mouse model of globoid cell leukodystrophy : implication for therapeutic strategiesSemantic proximity Read ↗

Establishment and characterization of spontaneously immortalized Schwann cells from murine model of globoid cell leukodystrophy (twitcher).Semantic proximity Read ↗

Significant correction of pathology in brains of twitcher mice following injection of genetically modified mouse neural progenitor cells.Semantic proximity Read ↗

Globoid Cell Leukodystrophy (Krabbe Disease): An UpdateSemantic proximity Read ↗

Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's DiseaseSemantic proximity Read ↗

The twitcher mouse: a model for Krabbe disease and for experimental therapies.Semantic proximity Read ↗

Insights into the Pathogenesis and Treatment of Krabbe Disease.Semantic proximity Read ↗

20 Years with SGBS cells - a versatile in vitro model of human adipocyte biologySemantic proximity Read ↗

Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease.Semantic proximity Read ↗

Combined hematopoietic and lentiviral gene‐transfer therapies in newborn Twitcher mice reveal contemporaneous neurodegeneration and demyelination in Krabbe diseaseSemantic proximity Read ↗

Tafazzin deficiency in mouse mesenchymal stem cells potentiates their immunosuppression and impairs activated B lymphocyte immune functionSemantic proximity Read ↗

Murine model of genetic demyelinating disease: The twitcher mouseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.