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Article

Expression and purification of functional recombinant epitopes for the platelet antigens, PlA1 and PlA2.

Blood - 15 Aug 1994

Barron-Casella E A, Kickler T S, Rogers O C, Casella J F

Abstract excerpt

The platelet antigens, PlA1 and PlA2, are responsible for most cases of posttransfusion purpura (PTP) and neonatal alloimmune thrombocytopenia (NAIT) in the caucasian population and are determined by two allelic forms of the platelet glycoprotein GPIIIa gene. To study the interaction between these antigens and their respective antibodies, we inserted the sequence that encodes the signal peptide and the N-terminal...

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PMID: 7519475

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