Article
Expression and purification of functional recombinant epitopes for the platelet antigens, PlA1 and PlA2.
Blood - 15 Aug 1994
Barron-Casella E A, Kickler T S, Rogers O C, Casella J F
Abstract excerpt
The platelet antigens, PlA1 and PlA2, are responsible for most cases of posttransfusion purpura (PTP) and neonatal alloimmune thrombocytopenia (NAIT) in the caucasian population and are determined by two allelic forms of the platelet glycoprotein GPIIIa gene. To study the interaction between thes...
Topics
- Alleles
- Antibodies
- Autoimmune Diseases
- Base Sequence
- Chromatography, Affinity
- Cloning, Molecular
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Glutathione Transferase
- Humans
- Infant, Newborn
- Molecular Sequence Data
- Platelet Membrane Glycoproteins
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Protein Sorting Signals