Article
Characterization of a human platelet antigen-1a-specific monoclonal antibody derived from a B cell from a woman alloimmunized in pregnancy.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015
Eksteen Mariana, Tiller Heidi, Averina Maria, Heide Gøril, Kjaer Mette, Ghevaert Cedric, Michaelsen Terje E, Ihle Øistein, Husebekk Anne, Skogen Bjørn, Stuge Tor B
Abstract excerpt
Human platelet Ag (HPA)-1a, located on integrin β3, is the main target for alloantibodies responsible for fetal and neonatal alloimmune thrombocytopenia (FNAIT) in the white population. There are ongoing efforts to develop an Ab prophylaxis and therapy to prevent or treat FNAIT. In this study, an mAb specific for HPA-1a, named 26.4, was derived from an immortalized B cell from an alloimmunized woman who had an...
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