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Article

Oestrogen replacement therapy may improve memory functioning in the absence of APOE epsilon4.

Journal of Alzheimer's disease : JAD - 1 Jun 2004

Burkhardt M S, Foster J K, Laws S M, Baker L D, Craft S, Gandy S E, Stuckey B G A, Clarnette R, Nolan D, Hewson-Bower B, Martins R N

Abstract excerpt

There is currently intense controversy regarding the use of hormone replacement therapy (HRT) in postmenopausal women, in relation to its therapeutic efficacy in Alzheimer's disease (AD). It has been suggested that the benefits of HRT may be modified by apolipoprotein E (APOE) genotype (the major genetic risk factor for AD). Here we report the findings of the first study designed to systematically explore the...

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Source

Identifiers

PMID: 15201477
DOI: 10.3233/jad-2004-6302

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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