Article
Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice.
Kidney international - 1 Jul 2004
Peng Min, Jarett Leonard, Meade Ray, Madaio Michael P, Hancock Wayne W, George Alfred L, Neilson Eric G, Gasser David L
Abstract excerpt
BACKGROUND: Mice that are homozygous for the kidney disease (kd) mutation are apparently healthy for the first 8 weeks of life, but spontaneously develop a severe form of interstitial nephritis that progresses to end-stage renal disease (ESRD) by 4 to 8 months of age. By testing for linkage to microsatellite markers, we previously localized the kd gene to a YAC/BAC contig. METHODS: The sequence of the entire...
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