Article
Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2.
American journal of physiology. Renal physiology - 1 Nov 2008
Saiki Ryoichi, Lunceford Adam L, Shi Yuchen, Marbois Beth, King Rhonda, Pachuski Justin, Kawamukai Makoto, Gasser David L, Clarke Catherine F
Abstract excerpt
Homozygous mice carrying kd (kidney disease) mutations in the gene encoding prenyl diphosphate synthase subunit 2 (Pdss2kd/kd) develop interstitial nephritis and eventually die from end-stage renal disease. The PDSS2 polypeptide in concert with PDSS1 synthesizes the polyisoprenyl tail of coenzyme...
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