CD8+ T Cell Phenotype and Function in Childhood and Adult-Onset Connective Tissue Disease.

doi:10.3390/ijms231911431

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Article

CD8+ T Cell Phenotype and Function in Childhood and Adult-Onset Connective Tissue Disease.

International journal of molecular sciences - 28 Sept 2022

Radziszewska Anna, Moulder Zachary, Jury Elizabeth C, Ciurtin Coziana

Abstract excerpt

CD8+ T cells are cytotoxic lymphocytes that destroy pathogen infected and malignant cells through release of cytolytic molecules and proinflammatory cytokines. Although the role of CD8+ T cells in connective tissue diseases (CTDs) has not been explored as thoroughly as that of other immune cells, research focusing on this key component of the immune system has recently gained momentum. Aberrations in cytotoxic...

Topics

CD8-Positive T-Lymphocytes
Connective Tissue Diseases
Cytokines
Humans
Lupus Erythematosus, Systemic
Phenotype
Polymyositis
Scleroderma, Systemic
Sjogren's Syndrome

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Identifiers

PMID: 36232733
DOI: 10.3390/ijms231911431
PMCID: PMC9569696

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