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Article

<i>HER-2</i> gene amplification can be acquired as breast cancer progresses

11 Jun 2004

Abstract excerpt

Amplification and overexpression of the HER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between primary tumor and metastases. Therefore, patients with HER-2-negative primary tumors rarely will receive anti-Her-2 antibody (trastuzumab, Herceptin) therapy. A very sensitive blood test was used to capture circulating tumor cells (CTCs) and evaluate their HER-2 gene...

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Identifiers

PMID: 15194824
DOI: 10.1073/pnas.0402993101

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