Article
Simultaneous detection of <i>HER2/neu</i> gene amplification and protein overexpression in paraffin‐embedded breast cancer
24 Feb 2005
Abstract excerpt
The determination of HER2/neu status in breast carcinomas has become essential for the selection of breast cancer patients for Herceptin therapy. Herceptin treatment is used in patients with metastatic breast carcinoma with HER2/neu protein overexpression detected by immunohistochemistry (IHC) or gene amplification analysed by fluorescence in situ hybridization (FISH). A multiparametric fluorescent approach based...
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