Article
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
Biochemical and biophysical research communications - 9 Jul 2004
Hofmann Heike, Geier Martina, Marzi Andrea, Krumbiegel Mandy, Peipp Matthias, Fey Georg H, Gramberg Thomas, Pöhlmann Stefan
Abstract excerpt
The angiotensin converting enzyme 2 (ACE2) has been identified as a receptor for the severe acute respiratory syndrome associated coronavirus (SARS-CoV). Here we show that ACE2 expression on cell lines correlates with susceptibility to SARS-CoV S-driven infection, suggesting that ACE2 is a major receptor for SARS-CoV. The soluble ectodomain of ACE2 specifically abrogated S-mediated infection and might therefore...
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