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Article

Genetic background of osteonecrosis: associated with thrombophilic mutations?

Clinical orthopaedics and related research - 1 May 2004

Zalavras Charalampos G, Vartholomatos George, Dokou Eleni, Malizos Konstantinos N

Abstract excerpt

Intravascular coagulation is considered a major pathogenetic mechanism for nontraumatic osteonecrosis. The aim of our study was to evaluate the association of thrombophilic factor V G1691A mutation (factor V Leiden) and G20210A prothrombin mutation with the disease. Mutation presence was investigated by polymerase chain reaction techniques in a study population of 72 adult Caucasian patients with osteonecrosis of...

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PMID: 15187864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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