Article
Role of alpha-adducin DNA polymorphisms in the genetic predisposition to diabetic nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Aug 2004
Conway Bryan R, Martin Rosalind, McKnight Amy-Jayne, Savage David A, Brady Hugh R, Maxwell Alexander P
Abstract excerpt
BACKGROUND: There is substantial evidence for genetic susceptibility to diabetic nephropathy. In particular, genes that predispose to hypertension in the general population may confer susceptibility to nephropathy in patients with diabetes. A Gly460Trp variant in the alpha-adducin gene has been associated with essential hypertension. Our aim was to screen the alpha-adducin gene for polymorphisms and to determine...
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