Article
Ectopic expression of a cecropin transgene in the human malaria vector mosquito Anopheles gambiae (Diptera: Culicidae): effects on susceptibility to Plasmodium.
Journal of medical entomology - 1 May 2004
Kim Won, Koo Hyeyoung, Richman Adam M, Seeley Douglas, Vizioli Jacopo, Klocko Andrew D, O'Brochta David A
Abstract excerpt
Genetically altering the disease vector status of insects using recombinant DNA technologies is being considered as an alternative to eradication efforts. Manipulating the endogenous immune response of mosquitoes such as the temporal and special expression of antimicrobial peptides like cecropin may result in a refractory phenotype. Using transgenic technology a unique pattern of expression of cecropin A (cecA)...
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