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Article

The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer.

Nature genetics - 1 Jul 2004

Lipkin Steven M, Rozek Laura S, Rennert Gad, Yang Wei, Chen Peng-Chieh, Hacia Joseph, Hunt Nathan, Shin Brian, Fodor Steve, Kokoris Mark, Greenson Joel K, Fearon Eric, Lynch Henry, Collins Francis, Gruber Stephen B

Abstract excerpt

Most susceptibility to colorectal cancer (CRC) is not accounted for by known risk factors. Because MLH1, MSH2 and MSH6 mutations underlie high-penetrance CRC susceptibility in hereditary nonpolyposis colon cancer (HNPCC), we hypothesized that attenuated alleles might also underlie susceptibility to sporadic CRC. We looked for gene variants associated with HNPCC in Israeli probands with familial CRC unstratified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15184898
DOI: 10.1038/ng1374

Genes

MLH1
MSH2
MSH6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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