Article
[HUP98-HOXA9 transgenic mice are susceptible to N-ethyl-N-nitrosourea stimulation in leukemogenesis].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 May 2004
Lu Shun-yuan, Gu Ming-min, Wang Yang, Tan Yi, Sun Yue-ping, Wang Long, Kong Hui, Lu Zhen-yu, Wang Zhu-gang
Abstract excerpt
OBJECTIVE: In order to investigate the leukemogenic potential of NUP98-HOXA9 fusion gene in vivo. METHODS: Molecular cloning technology was used to construct NUP98-HOXA9 transgenic plasmid and NUP98-HOXA9 transgenic mice were generated. The genotype and phenotype of the NUP98-HOXA9 transgenic mice were analyzed by PCR, RT-PCR and colony-forming assay. The effect of N-ethyl-N-nitrosourea (ENU) stimulation on the...
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