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Article

Fungal metabolic model for type I 3-methylglutaconic aciduria.

The Journal of biological chemistry - 30 Jul 2004

Rodríguez José M, Ruíz-Sala Pedro, Ugarte Magdalena, Peñalva Miguel A

Abstract excerpt

Aspergillus nidulans catabolizes Leu to acetyl-CoA and acetoacetate through a pathway homologous to that used by humans. Fungal hlyA encodes a bifunctional polypeptide comprising the last two enzymes in this pathway, 3-methylglutaconyl-CoA hydratase and 3-hydroxy-3-methylglutaryl-CoA lyase. hlyA transcription is specifically induced by Leu. A Delta hlyA mutation removing the complete 3-methylglutaconyl-CoA...

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Identifiers

PMID: 15181004
DOI: 10.1074/jbc.M313044200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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