Article
Rationale for diagnosing human prion disease.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Apr 2004
Kovács Gábor G, Voigtländer Till, Gelpi Ellen, Budka Herbert
Abstract excerpt
Human prion diseases (PrD) like Creutzfeldt-Jakob disease (CJD) include sporadic, acquired and familial neurodegenerative disorders. The central events in the neuropathological process of PrDs are severe neuronal loss, spongiform change and accumulation of abnormal prion protein (PrPSc). The latter is a conformational variant of the host-encoded cellular PrP (PrPC), a copper-binding protein. The physiological...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.