Article
Molecular diagnosis of human prion disease.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008
Wadsworth Jonathan D F, Powell Caroline, Beck Jonathan A, Joiner Susan, Linehan Jacqueline M, Brandner Sebastian, Mead Simon, Collinge John
Abstract excerpt
Human prion diseases are associated with a range of clinical presentations, and they are classified by both clinicopathological syndrome and etiology, with subclassification according to molecular criteria. Here, we describe procedures that are used within the MRC Prion Unit to determine a molecular diagnosis of human prion disease. Sequencing of the PRNP open reading frame to establish the presence of pathogenic...
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