Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Microdomain for Protein Secretion in Gram-Positive Bacteria

3 Jun 2004

Abstract excerpt

Gram-positive bacteria face unique challenges in generating biologically active conformations for their exported proteins because they lack a dedicated compartment for folding secreted polypeptides. We have discovered that protein secretion by way of the general secretory (Sec) pathway in the important human pathogen Streptococcus pyogenes proceeds through a single microdomain. Unlike other mechanisms for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neonatal and Maternal Infections
Share to Plant Pathogenic Bacteria Studies
Share to Streptococcal Infections and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15178803
DOI: 10.1126/science.1097404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Microdomain for Protein Secretion in Gram-Positive BacteriaPMID 15178803Read ↗

The ExPortal: an organelle dedicated to the biogenesis of secreted proteins in Streptococcus pyogenes.Semantic proximity Read ↗

Structure of the nonameric bacterial amyloid secretion channelSemantic proximity Read ↗

Assembly and mechanisms of bacterial type IV secretion machinesSemantic proximity Read ↗

Type V Protein Secretion Pathway: the Autotransporter StorySemantic proximity Read ↗

Type VII Secretion: A Highly Versatile Secretion SystemSemantic proximity Read ↗

Translocation of proteins across the cell envelope of Gram-positive bacteriaSemantic proximity Read ↗

Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates.Semantic proximity Read ↗

IcsA, a polarly localized autotransporter with an atypical signal peptide, uses the Sec apparatus for secretion, although the Sec apparatus is circumferentially distributed.Semantic proximity Read ↗

Structural insights into the mechanism of a novel protein targeting pathway in Gram-negative bacteria.Semantic proximity Read ↗

Anniversary of the discovery of sec mutants by Novick and Schekman.Semantic proximity Read ↗

Membrane protein sequence features direct post-translational insertionSemantic proximity Read ↗

Anionic lipids enriched at the ExPortal of Streptococcus pyogenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.