Article
Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jan 2005
Drake Amanda J, Walker Brian R, Seckl Jonathan R
Abstract excerpt
Epidemiological studies linking low birth weight and subsequent cardiometabolic disease have given rise to the hypothesis that events in fetal life permanently program subsequent cardiovascular risk. The effects of fetal programming may not be limited to the first-generation offspring. We have explored intergenerational effects in the dexamethasone-programmed rat, a model in which fetal exposure to excess...
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