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Article

Sex differences in early-life programming of the hypothalamic–pituitary–adrenal axis in humans

16 Sept 2017

Abstract excerpt

Increasing evidence supports fetal glucocorticoid exposure with associated altered offspring hypothalamic-pituitary-adrenal (HPA) axis activity as a key mechanism linking early life events with later life disease. Alterations in HPA axis activity are linked to a range of cardiometabolic and psychiatric diseases. As many of these diseases manifest sex differences in presentation we review the evidence for...

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PMID: 28927573
DOI: 10.1016/j.earlhumdev.2017.09.011

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