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Article

Activity-dependent homeostatic specification of transmitter expression in embryonic neurons.

Nature - 3 Jun 2004

Borodinsky Laura N, Root Cory M, Cronin Julia A, Sann Sharon B, Gu Xiaonan, Spitzer Nicholas C

Abstract excerpt

Neurotransmitters are essential for interneuronal signalling, and the specification of appropriate transmitters in differentiating neurons has been related to intrinsic neuronal identity and to extrinsic signalling proteins. Here we show that altering the distinct patterns of Ca2+ spike activity spontaneously generated by different classes of embryonic spinal neurons in vivo changes the transmitter that neurons...

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PMID: 15175743
DOI: 10.1038/nature02518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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