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Article

Calcium-dependent regulation of the enkephalin phenotype by neuronal activity during early ontogeny.

Journal of neuroscience research - 1 Jan 1991

Agoston D V, Eiden L E, Brenneman D E

Abstract excerpt

Genetic components of the neuronal phenotype are regulated by epigenetic factors--trophic molecules and neuronal activity--during neurodifferentiation. Developing neurons in dissociated cultures of embryonic mouse spinal cord show spontaneous electrical activity after one week in culture. We now report that the blockade of this spontaneous electrical activity for two days with tetrodotoxin (TTX) causes virtually...

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Identifiers

PMID: 1645773
DOI: 10.1002/jnr.490280115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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