Calcium-dependent regulation of the enkephalin phenotype by neuronal activity during early ontogeny.

doi:10.1002/jnr.490280115

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Article

Calcium-dependent regulation of the enkephalin phenotype by neuronal activity during early ontogeny.

Journal of neuroscience research - 1 Jan 1991

Agoston D V, Eiden L E, Brenneman D E

Abstract excerpt

Genetic components of the neuronal phenotype are regulated by epigenetic factors--trophic molecules and neuronal activity--during neurodifferentiation. Developing neurons in dissociated cultures of embryonic mouse spinal cord show spontaneous electrical activity after one week in culture. We now...

Topics

Animals
Calcium
Calcium Channel Blockers
Enkephalin, Methionine
Enkephalins
Ganglia, Spinal
Gene Expression Regulation
Ion Channel Gating
Membrane Potentials
Mice
Mice, Inbred C57BL
Neuronal Plasticity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

Nicotinic Acids

Oxadiazoles

Phenotype

Protein Precursors

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 1645773
DOI: 10.1002/jnr.490280115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1645773-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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