Article
Altered activity of signaling pathways in diaphragm and tibialis anterior muscle of dystrophic mice.
Experimental biology and medicine (Maywood, N.J.) - 1 Jun 2004
Lang Joshua M, Esser Karyn A, Dupont-Versteegden Esther E
Abstract excerpt
Duchenne muscular dystrophy is a musculoskeletal disease caused by mutations in the dystrophin gene. The purpose of this study was to use the mouse model of muscular dystrophy (mdx) to determine if the progression of the dystrophic phenotype in the diaphragm (costal) versus limb skeletal muscle (tibialis anterior) is associated with specific changes in extracellular regulated kinase (ERK1/2), p70 S6 kinase...
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