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Article

[Construction of mutants of MHC class II molecule transactivator gene capable of suppressing HLA-DR/DQ expression and exploration on their mechanism].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology - 1 Sept 2003

Ou Qi-shui, Lin Lin, Huang Li-dong, Lu Pei-hua, Zhou Guan-yan

Abstract excerpt

AIM: To construct MHC class II transactivator (CIITA) gene mutants which could suppress the expression of MHC class II molecule and explore its mechanism. METHODS: Restrictive enzymes digestion, PCR and synthesized oligonucleotide strands were used to construct three mutants including pcDNA3mCIITA2, pcDNA3mCIITA3 and pcDNA3mCIITA4. These mutants and pcDNA3 vector were transfected into Hela and Raji cell lines by...

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Identifiers

PMID: 15169643

Genes

CIITA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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