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Article

The MHC-II transactivator CIITA inhibits Tat function and HIV-1 replication in human myeloid cells.

Journal of translational medicine - 18 Apr 2016

Forlani Greta, Turrini Filippo, Ghezzi Silvia, Tedeschi Alessandra, Poli Guido, Accolla Roberto S, Tosi Giovanna

Abstract excerpt

BACKGROUND: We previously demonstrated that the HLA class II transactivator CIITA inhibits HIV-1 replication in T cells by competing with the viral transactivator Tat for the binding to Cyclin T1 subunit of the P-TEFb complex. Here, we analyzed the anti-viral function of CIITA in myeloid cells, another relevant HIV-1 target cell type. We sinvestigated clones of the U937 promonocytic cell line, either permissive...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid Cells

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Terminal Repeat Sequences

Share to Trans-Activators

Share to Transcriptional Activation

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 27089879
DOI: 10.1186/s12967-016-0853-5
PMCID: PMC4835826

Genes

CIITA
TRIM22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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