Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic myelogenous leukemia with acquired c-kit activating mutation and transient bone marrow mastocytosis.

The hematology journal : the official journal of the European Haematology Association - 1 Jan 2004

Cairoli Roberto, Grillo Giovanni, Beghini Alessandro, Cornacchini Giorgia, Larizza Lidia, Morra Enrica

Abstract excerpt

Mutations of the c-kit gene have been reported in myeloproliferative disorders. We describe here a case of Ph+ (b2a2) chronic myelogenous leukemia that, during the course of disease, showed an unusual bone marrow mast-cell infiltration. A mutational screening for the c-kit gene, performed on DNA routinely cryopreserved during the follow-up, evidenced the D816Y-activating mutation as an additional genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to BCR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Mastocytosis

Share to Mutation

Share to Proto-Oncogene Proteins c-kit

Source

Identifiers

PMID: 15167915
DOI: 10.1038/sj.thj.6200348

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Chronic myelogenous leukemia with acquired c-kit activating mutation and transient bone marrow mastocytosis.PMID 15167915Read ↗

JAK2-positive myeloproliferative neoplasm co-existing with systemic mastocytosis.Semantic proximity Read ↗

Mutations and chromosomal rearrangements of JAK2: not only a myeloid issue.Semantic proximity Read ↗

Chronic mast cell leukaemia with exon 9 KIT mutation A502_Y503dup: a rare imatinib responsive variant.Semantic proximity Read ↗

Abnormality of c-kit oncoprotein in certain patients with chronic myelogenous leukemia – potential clinical significanceSemantic proximity Read ↗

Systemic mastocytosis associated with acute myeloid leukaemia: report of two cases and detection of the c‐kit mutation Asp‐816 to ValSemantic proximity Read ↗

Development of chronic myeloid leukemia in a patient previously diagnosed with a JAK2-positive myeloproliferative neoplasm.Semantic proximity Read ↗

C-kit mutations and mast cell disorders. A model of activating mutations of growth factor receptors.Semantic proximity Read ↗

Acute myeloid leukaemia with t(8;21) associated with "occult" mastocytosis. Report of an unusual case and review of the literature.Semantic proximity Read ↗

In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation.Semantic proximity Read ↗

Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.